Nichtsteroidale Antiphlogistika Thrombophlebitis
Nichtsteroidale Antiphlogistika Thrombophlebitis

Wirkstoffe: Betamethasondihydrogenphosphat-Dinatrium (Ph.Eur.), Betamethasondipropionat (Ph.Eur.).

Nichtsteroidale Antiphlogistika Thrombophlebitis

This page includes the following topics and synonyms: Nonsteroidal Anti-inflammatory, Non-Steroidal Antiinflammatory, Non-Opioid Analgesics, NSAID.

These images are a random sampling from a Bing Spezialisten Varizen on the term "Nonsteroidal Anti-inflammatory. Search Bing for all related images. Started inthis collection nichtsteroidale Antiphlogistika Thrombophlebitis contains interlinked topic pages divided into a tree of 31 specialty books and chapters. Content is updated monthly with systematic literature reviews and conferences.

Although access to this website is not restricted, the information found here is intended for use by medical providers.

Patients should address specific medical concerns with their physicians. Mechanism Precautions Adverse Effects Monitoring: Related Bing Images Extra: Precautions Peptic ulcer risk, nephrotoxicity, and cardiovascular risk are FDA black box warnings. Salicylates Acetylsalicylic acid Aspirin mg q hours Trisalicylate Trilisate mg q hours Diflunisal Dolobid mg q hours Nichtsteroidale Antiphlogistika Thrombophlebitis and longer acting than Aspirin mg Superior and longer acting than Acetaminophen mg Salsalate Disalcid Sodium Salicylate Uracil 5 Sodium thiosalicylate Tusal.

Oxicams Gene ral Long half life once a day dosing Meloxicam Mobic 7. Diclofenac Potassium Cataflam 50 mg orally every 8 hours Comparable to Aspirin Faster absorption hence faster onset than diclofenac Sodium voltaren Diclofenac XR mg orally daily Arthrotec 50 mg Diclofenac with mcg Misoprostel Zorvolex 18 or 35 mg orally every 8 hours Released in as expensive, lower dose version of Diclofenac Potassium 50 mg No evidence of improved safety or similar efficacy to the lower priced, higher dose 50 mg tablet Recommendations are still to use other systemic NSAIDs instead of diclofenac Nichtsteroidale Antiphlogistika Thrombophlebitis Lett 21 2: Related links to external sites from Bing.

Definition MSH Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, nichtsteroidale Antiphlogistika Thrombophlebitis, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.

Definition NCI Anti-inflammatory agents that are not steroids. They are used primarily in the treatment of chronic arthritic conditions and certain soft tissue disorders associated with pain and inflammation. MeSH Definition CSP agents that counteract or suppress inflammation and are not steroids; most have in addition analgesic, antipyretic, and platelet-inhibitory actions; they act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins: Related Topics in Analgesic Medications.

Pharmacology - Analgesic Medications Pages. Back Links pages that link to this page. Search other sites for 'Nonsteroidal Anti-inflammatory'. Anti-inflammatory agents that are non-steroidal in nature, nichtsteroidale Antiphlogistika Thrombophlebitis. A nichtsteroidale Antiphlogistika Thrombophlebitis of drugs that decrease fever, nichtsteroidale Antiphlogistika Thrombophlebitis, swelling, pain, and redness.

Anti-inflammatory agents that are not steroids. Antiphlogistika, nichtsteroidaleEntzündungshemmende Mittel, nichtsteroidaleNichtsteroidale entzündungshemmende Mittel.

The composition for the treatment of all forms of thrombosis, especially thrombophlebitis, Der Einsatz als nichtsteroidale Antiphlogistika.

Die Erfindung betrifft teilweise neue 1- 2-Hydroxyaryl -alkanon-oxime, Verfahren zu ihrer Herstellung und ihre Anwendung in pharmazeutischen Zubereitungen. The invention relates in part to new 1- 2-hydroxyaryl alkaneone-oxime, processes for their preparation and their use in nichtsteroidale Antiphlogistika Thrombophlebitis preparations The invention relates in part to new 1- 2-hydroxyaryl alkaneone-oxime, processes for their preparation and their use in pharmaceutical preparations.

Aufgabe der Erfindung ist die Entwicklung von 1- 2-Hydroxyaryl -alkanon-oximen mit wertvollen pharmakologischen Eigenschaften. The object of the invention is the development of 1- 2-hydroxyaryl alkaneone-oximes having valuable pharmacological properties. First Pharmazeutische Zusammensetzungen, gekennzeichnet durch einen Gehalt an 1- 2-Hydroxyaryl -alkanon-oximen der allgemeinen Formel I Pharmaceutical compositions characterized by a content of 1- 2-hydroxyaryl alkaneone-oximes of the general formula I.

Verwendung von pharmazeutischen Zusammensetzungen nach Punkt 1 oder Verbindungen nach Punkt 2 als universelle Lipoxygenasehemmer. Use of pharmaceutical compositions according to item 1 or compounds nichtsteroidale Antiphlogistika Thrombophlebitis to item 2 as a universal lipoxygenase inhibitor, nichtsteroidale Antiphlogistika Thrombophlebitis.

A composition for the treatment of all allergic diseases, especially atopic dermatitis, allergic rhinitis, urticaria, angioedema, contact dermatitis, allergic conjunctivitis and allergic disorders of the gastrointestinal tract, characterized by containing one or more active ingredients according to item 1 or the second, nichtsteroidale Antiphlogistika Thrombophlebitis.

A composition for the treatment of inflammatory diseases, in particular those in which the conventional antiinflammatory drugs, whose application point is not the Lipoxygenese 'show insufficient therapeutic effects, particularly in purulent inflammations and rheumatic and arthritic diseases, characterized by the content of one or more active ingredients according to item 1 or the second.

The composition for the treatment of all forms of thrombosis, nichtsteroidale Antiphlogistika Thrombophlebitis, especially thrombophlebitis, and for prophylaxis of thrombosis in chronically ischemic heart disease, post-treatment at Myokardinfekt, chronic recurrent thrombosis and chronic thrombophlebitis, characterized by the content of one or more active ingredients according to item 1 or the second.

A composition for use as antiatherosclerotic, gastroprotective or antimetastatic drugs, characterized by the content of one or more active ingredients according to item 1 or the second. A composition for the treatment of all forms of arterial hypertension, in particular arterial hypertension in the pulmonary circulationcharacterized by the content of one or more active ingredients according to item 1 or the second.

A composition for use as spasmolytics for the treatment of spastic conditions of the smooth musculature of various origins, especially in different sections of the digestive and urogenital tracts and the blood vessel musculature, characterized by the content of one or more active ingredients according to item 1 or the second.

A medicament containing at least one compound of, formula I according to point 1 in combination with at least one of the traditional antiallergic, antiasthmatic, antiphlogistic, antihypertensive, nichtsteroidale Antiphlogistika Thrombophlebitis.

A process for the preparation of the ketones nichtsteroidale Antiphlogistika Thrombophlebitis according to item 13, characterized in that an optional further phenolic hydroxyl group is etherified with an nichtsteroidale Antiphlogistika Thrombophlebitis agent, preferably with alkyl, aralkyl or Cycloalkylbromiden or chlorides in the presence of a basic substance. The method of item 13 and 14, characterized in that the etherification is carried out in low boiling alkyl glycols.

A process for the preparation of medicaments, characterized in that pharmaceutical compositions according to item 1 or compounds according to point 2, if appropriate together with excipients and carriers into a suitable administration form, are transferred. Titel der Erfindung Title of the invention [] []. Die Verbindun- ,gen als solche und die sie enthaltenden pharmazeutischen Mittel zeigen wertvolle nichtsteroidale Antiphlogistika Thrombophlebitis, insbesondere antiasthmatische, antianaphylaktische, antiphlogistische, nichtsteroidale Antiphlogistika Thrombophlebitis, antihypertensive, spasmolytische, antirheumatische und antithrombotische Eigenschaften und sind in der Human- und Veterinärmedizin für die Anwendung in der Therapie nichtsteroidale Antiphlogistika Thrombophlebitis Asthma bronchiale und anderer allergischer Erkrankungen, von entzündlichen und rheumatischen Erkrankungen verschiedener Art sowie der Thrombose geeignet.

The Verbindun- called as such and the pharmaceutical agents containing them exhibit valuable pharmacological, particularly antiasthmatic, anti-anaphylactic, anti-inflammatory, antihypertensive, antispasmodic, antirheumatic and antithrombotic properties and are used in human and veterinary medicine for use in the treatment of bronchial asthma and other allergic diseases, nichtsteroidale Antiphlogistika Thrombophlebitis, capable of inflammatory and rheumatic diseases of various kinds, as well as thrombosis.

Verfahren zur Herstellung von Ketoximen sind an sich hinreichend bekannt und in jedem Handbuch über organische Synthesen vgl. Weygand-Hilgetag, Organisch-Chemische Experimentierkunst zu finden. A process for producing nichtsteroidale Antiphlogistika Thrombophlebitis are well known and can be found in any handbook on organic synthesis cf.

Für die Umsetzung von 1-Aryl-alkanonen mit Die erste Stufe, wie Krampfadern zu behandeln zu den-Oximen sind in der Literatur verschiedene Methoden beschrieben.

For the reaction of 1-aryl-alkaneones with hydroxylamine to oximes different methods are described in the literature. Allerdings sind dabei häufig die Reaktionsbedingungen wie Reaktionszeiten, Art der verwendeten Base ua in Abhängigkeit von der Struktur des Ausgangsketons nicht optimal gewählt. However, while the reaction conditions such as reaction time, type of base used often include non-optimally selected depending on the structure of the starting ketone. Von den nichtsteroidale Antiphlogistika Thrombophlebitis zeichnen sich besonders die 1- 2-Hydroxyphenyl -alkanon-oxime durch ihre Verwendung in der Metallanalytik als Metallreagentien und in der Hydrometallurgie als selektive Metallextraktionsmittel für die Flüssig-Flüssig-Extraktion aus BRD-OS Of the 1-aryl-alkanone oximes especially the nichtsteroidale Antiphlogistika Thrombophlebitis 2-hydroxyphenyl drawing alkaneon-oxime by its use in metal analysis as metal reagents and in hydrometallurgy as selective metal extractant for the liquid -liquid extraction from BRD-OS 2, nichtsteroidale Antiphlogistika Thrombophlebitis, The 5-iso-nonylhydroxy-acetophenone-oxime SME by Shell Chemicals has for the recovery of nichtsteroidale Antiphlogistika Thrombophlebitis industrial importance Extr.

Über eine Anwendung dieser Verbindungen als Pharmaka in der Human- und Veterinärmedizin wurden keinerlei Angaben gefunden. About an application of these compounds as pharmaceuticals in human and veterinary medicine no information has been found.

Ziel der Erfindung ist die Bereitstellung von pharmazeutischen Zubereitungen mit pharmakologisch wertvollen, insbesondere antiasthmatischen, antianaphylaktischen, nichtsteroidale Antiphlogistika Thrombophlebitis, antiphlogistischen, antirheumatischen, antihypertensiven, spasmolytischen und antithrombotischen Eigenschaften.

The aim of the invention is the provision of pharmaceutical formulations with pharmacologically valuable, especially anti-asthmatic, antianaphylaktischen, antiphlogistic, antirheumatic, anti-hypertensive, anti-thrombotic and spasmolytic properties, nichtsteroidale Antiphlogistika Thrombophlebitis. Aufgabe der Erfindung ist die Entwicklung von teilweise neuen 1- 2-Hydroxyaryl -alkanon-oximen mit antiasthmatischen und weiteren pharmakologisch wertvollentEigenschaften, die auf der Hemmung der Lipoxygenase beruhen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel.

The object of the invention is the development of some new 1- 2-hydroxyaryl alkaneone-oximes with anti-asthmatic and other pharmacologically worth fully properties, which are based on the inhibition of lipoxygenase, to processes for their preparation and their use as medicaments. Falls das entstandene Keton noch eine weitere Hydroxylgruppe enthält, wird diese mit einem Alkylierungsmittel, z. Alkylhalogeniden, Aralkyl- oder Cycloalkylbromid- oder chlorid, vorzugsweise jedoch mit einem Alkylbromid verethert.

If the resulting ketone contains an additional hydroxyl group, this with an alkylating agent, for. Example, alkyl halides, aralkyl or Cycloalkylbromid- or chloride, but preferably etherified with an alkyl bromide. Das Keton wird dann in bekannter Weise mit Hydroxylaminhydrochlorid oder einem anderen geeigneten Hydroxylaminsalz in basischem Medium zum Oxim umsetzt. The ketone is then reacted in known manner with hydroxylamine hydrochloride or other suitable salt of hydroxylamine in a basic medium to give the oxime.

Es können dazu anorganische oder organische Basen verwendet werden, wie z. Natrium- oder Kaliumhydroxid, Calciumhydroxid, Natrium- oder Kaliumcarbonat, Natriumhydrogencarbonat, Natrium- oder Kaliumacetat, Natriumformiat, Pyridin, Piperidin, Morpholin, N-Methylpiperazin, Diethanolamin ua Die Veretherung und die Oximierung werden in organischen Lösungsmitteln durchgeführt, die Veretherung erfolgt vorzugsweise in Aceton oder niederen aliphatischen Alkoholen unter Zusatz eines vorstehend aufgeführten basischen Stoffes, insbesondere Kaliumcarbonat oder Natriumhydroxid, die Oximbildung in niederen aliphatischen Alkoholen bzw.

It can do this inorganic or organic bases Varizen und Seil used, such as. For example, nichtsteroidale Antiphlogistika Thrombophlebitis, sodium or potassium hydroxide, calcium hydroxide, sodium or potassium nichtsteroidale Antiphlogistika Thrombophlebitis, sodium bicarbonate, sodium or potassium Krampfadern ist eine chronische, sodium formate, pyridine, piperidine, morpholine, N-methylpiperazine, diethanolamine, etc.

Die Reaktionszeiten für die Alklierungsreaktion liegen zwischen 15 und 30 Stunden und für die Oximierungsreaktion zwischen 15 Minuten und 3 Stunden Nach diesem Verfahren konnten auch neue, in der Literatur bisher nicht beschriebene und hinsichtlich Elementaranalyse, Schmelzpunkt und IR-spektraler Eigenschaften charakterisierte Verbindungen erhalten werden, die in Tabelle 1 zusammengestellt sind. The reaction times for the Alklierungsreaktion be between 15 and 30 hours and for the oximation reaction between 15 minutes and 3 hours by this process could be obtained also new, previously described in the literature and characterized with regard to elemental analysis, melting point and IR spectral characteristics compounds are summarized in table 1 below.

Surprisingly, it was found that Varbindungen the invention of the general formula I show in animal studies in vitro and in vivo pronounced anti-asthmatic, anti-allergic and anti-anaphylactic effects. Die Prüfung auf die genannten pharmakologischen Eigenschaften erfolgte z.

Beispiel 16 und der isolierten Arteria pulmonalis vgl. Beispiel 18 sowie an der spezifisch-allergisch induzierten Bronchokonstriktion an Ovalbumin-sensibilisierten narkotisierten und künstlich beatmeten Meerschweinchen "Meerschweinchenasthma" bzw.

The check for the above-mentioned pharmacological properties were z. Diamantis, JL Melton; W. Diamantis, JL Melton; D. The compounds of general formula I according to the invention lead to a complete inhibition of ovalbumin-induced asthma response in ovalbumin-sensitized guinea pigs. This effect in allergic asthma is similar to ketotifen, a modern anti-asthmatic whose molecular Wirkungsmechaniamus but different from that of the compounds of the invention is different see below.

Weiterhin belegt die Hemmung der arachidonsäure-induzierten Kontraktion an der isolierten Arteria pulmonalis vom Kaninchen Beispiel 18 die antihypertensive und spasmolytische Wirkung. Furthermore, the inhibition of arachidonic acid-induced contraction on the isolated pulmonary artery of rabbit Example 18 occupies the antihypertensive and spasmolytic effect.

Nichtsteroidale Antiphlogistika Thrombophlebitis, it was concluded-that compounds of the invention of general formula I also have to have pronounced anti-inflammatory properties. This conclusion could in a suitable animal model of inflammation in vivo, the carrageenin-induced edema of the rat paw, according to the method of Winter et al. As a molecular target for the pharmacological effects of the compounds of the invention, the inhibition of lipoxygenase has been identified.

It is known that the metabolites of arachidonic acid formed by the enzyme lipoxygenase are involved in the development of inflammatory and allergic processes [see. Pharmacol, 32, ; J. Pharmacol, 32, ; B. Samuelsson, Trends in Pharmacol: Sci, Mai; B. Die Hemmung der Lipoxygenase wurde überzeugend an einer geeigneten tierischen Lipoxygenase nachgewiesen, die nach dem Verfahren von Rapoport und Mitarb. The inhibition of lipoxygenase was convincingly demonstrated in a suitable animal lipoxygenase according to the procedure of Rapoport et al.

The powerful inhibitions were detectable for a part of the inventive compounds also at a final concentration of 0. Durch Variation der Substanzkonzentration konnten die Titrationskurven der Hemmung und daraus die Halbhemmungskonzentrationen I 50 -Werte ermittelt werden. By varying the substance concentration in the titration curves of the inhibition and from this the half inhibition concentrations I 50 values were determined.

It was for the highly effective anti-asthmatic 5-methylhydrox y laurophenone oxime 7 uM. The suitability of Zipoxygenase from rabbit as a model for nichtsteroidale Antiphlogistika Thrombophlebitis molecular-pharmacological site of action of the compounds of the invention was demonstrated by the fact that other known from the literature such as lipoxygenase inhibitors.

The previously known Lipogygenasehemmer not achieve the anti-asthmatic activity of the compounds of the invention.

Beispiel 20 und die Lipoxygenase aus Erbsen. The inventive compounds also inhibit all investigated isolated from plant sources lipoxygenases, including the soybean lipoxygenase-1 see.

Example 20 and the lipoxygenase from peas. From these and other studies, the reasoning dass dünnt das Blut Varizen revealed that the inventive compounds represent inhibitors of lipoxygenases universal regardless of its origin and position specificity, nichtsteroidale Antiphlogistika Thrombophlebitis, resulting in a number of valuable pharmacological properties nichtsteroidale Antiphlogistika Thrombophlebitis obtained.

Buytenhek, Methods in Enzymology 86, 60isoliert wurde, bis zu einer Endkonzentration von 1 mM nicht nennenswert gehemmt wird. Of special interest is the observation that Thrombophlebitis der unteren Extremitäten vaskuläre Symptome other important enzyme of Arachidonsäureksakade, cyclooxygenase, which was prepared from the seminal vesicles of cattle by the method of FJG van der Ouderaa and M.

Buytenhek, Methods in Enzymology 86, 60isolated, is added to a final concentration of 1 mM is not significantly inhibited. Acetylsalicylsäure, nichtsteroidale Antiphlogistika Thrombophlebitis, Indometacin ua oder sowohl die Lipoxygenase als auch die Cyclooxygenase z.

Phenidon hemmen, woraus sich bei diesen bekannten Verbindungen unerwünschte pharmakologische Nebenwirkungen ergeben zB ulcerogene, gastrotoxische und proasthmatische Wirkungen der Acetylsalicylsäure.

In this nichtsteroidale Antiphlogistika Thrombophlebitis, compounds of the invention are superior to many previously known anti-inflammatory drugs that either inhibit only the cyclooxygenase eg.

As aspirin, indomethacin, etc. Für Krampfadern Drogen inhibition of lipoxygenase was identified as a molecular target for new drugs, including their effect on platelet aggregation was investigated.

The essential role of the lipoxygenase pathway for the irreversibility of platelet Novinet Varizen is known today [CE Dutilh et al.

Prostaglandins and Medicine 6, ]. Der Irreversibilität der Thrombozytenaggregation wird bei der Pathogenese thrombotischer Erkrankungen eine Schlüsselrolle zugeschrieben. The irreversibility of platelet aggregation is attributed a key role in the pathogenesis of thrombotic disorders. In den-Experimenten wurde die Thrombozytenaggregation entweder, nichtsteroidale Antiphlogistika Thrombophlebitis.

In the experiments, nichtsteroidale Antiphlogistika Thrombophlebitis, the platelet aggregation was triggered entweder. Die genannten Experimente belegen an geeigneten biologischen Modellen die antiasthmatischen, antiallergischen, antithrombotischen und antiinflammatorischen Effekte.

The experiments referred to demonstrate the anti-asthmatic, nichtsteroidale Antiphlogistika Thrombophlebitis, anti-allergic, anti-thrombotic and anti-inflammatory effects at suitable biological models, nichtsteroidale Antiphlogistika Thrombophlebitis. Als Indikationsgebiete in der Human- und Veterinärmedizin können beispielsweise genannt werden: Indication areas in human and veterinary medicine can be, for example: The classification of allergic reactions responsible for clinical hypersensitivity and disease.

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